I have tried both ways. Don't think there is any difference, but because each body, even if you think they are exactly the same, still usually post different times. So who's to know?
My SS normal build (w/o 45 wheel, AND w/o the PineCar NDFW) turned 2.9432 and 2.9424 on the red lane in the March Ice race #2.
Currently that's my best car. None of my others are within 1/100th, including 2 45's with and without the PineCar small wheel, as well as another SS with a PineCar wheel in normal position.
AND incidentally, my car "Upsized" DOES NOT use wheel weights. Go figure!